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Title:
Molecular Biology in Medicinal Chemistry (Methods and Principles in Medicinal Chemistry) |
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Division: General Biochemistry / John Wiely & Son / 英文版 |
Author/Editor: Theodor Dingermann Star:  |
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ISBN: 3527304312 |
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Introduce Date: 2006年08月21日12:50 , Release Date: 2006年08月21日12:56 |
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Introducer: anmin , Rate: 10/294 |
| Format: pdf(editorial) Download |
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| Appraiser: Reuben | Grade: +5 | Reason: ( 这本书还行 ) | |
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| Description: |
Molecular Biology in Medicinal Chemistry
Theodor Dingermann (Editor), Dieter Steinhilber (Editor), Gerd Folkers (Editor), Raimund Mannhold (Series Editor), Hugo Kubinyi (Series Editor)
ISBN: 3-527-30431-2
Hardcover
435 pages
April 2004
Wiley List Price: US $150.00
Book Description
Molecular Biology and Genetic Engineering have made a great impact on the methods and strategies of modern pharmaceutical and medicinal chemistry, transforming virtually every step in the drug development process, from target finding to drug design and ADMET analysis. Even the synthesis and manufacture of pharmaceutically active compounds has benefited from novel approaches based on molecular biology tools. From the Contents: Cellular Assays in Drug Discovery Transgenic Models Reporter Gene Assay Systems Stereoselective Synthesis with Recombinant Enzymes Nucleic Acid Drugs Enantioseparation of Chiral Drugs NMR-based Drug Discovery Pharmacogenomics and Toxicogenomics With its broad coverage and up-to-date treatment, this volume is essential reading for all pharmaceutical chemists, molecular biologists and medical researchers using molecular biology tools to study drugs and their action.
Preface.
Foreword.
Contributors.
PART I: MOLECULAR TARGETS.
1. Cellular Assays in Drug Discovery (H. Albrecht, et al.).
2. Gene Knockout Models (P. Ruth & M. Sausbier).
3. Reporter Gene Assay Systems for the Investigation of G-protein-coupled Receptors (M. Dinger & A. Beck-Sickinger).
4. From the Human Genome to New Drugs: The Potential of Orphan G-protein-coupled Receptors (R. Bakker & R. Leurs).
PART II: SYNTHESIS.
5. Stereoselective Synthesis with the Help of Recombinant Enzymes (N. Rao & A. Liese).
6. Nucleic Acid Drugs (J. Engels & J. Parsch).
PART III: ANALYSIS.
7. Recent Trends in Enantioseparation of Chiral Drugs (B. Chankvetadze).
8. Affinity Chromatography (G. Scriba).
9. Nuclear Magnetic Resonance-based Drug Discovery (U. Günther, et al.).
10.13C- and 15N-Isotopic Labeling of Proteins (C. Klammt, et al.).
11. Application of Antibody Fragments as Crystallization Enhancers (C. Hunte & C. Münke).
PART IV: KINETICS, METABOLISM AND TOXICOLOGY.
12. Pharmacogenetics: The Effect of Inherited Genetic Variation on Drug Disposition and Drug Response (K. Kesseler).
13. Pharmacogenomics of Bioavaliability and Elimination (I Cascorbi & H. Kroemer).
14. Toxicogenomics: Integration of New Molecular Biological Tools in Toxicology (W. Heijne, et al.).
Index.
"...a welcome addition to the library of anyone seeking to build a multidisciplinary group" (Applied Organometallic Chemistry, June 2004)
"In all, the book touches on some of the trendiest subjects that interface to form the frontier of modern medicinal chemistry." (Kevin G. Rice, Division of Medicinal and Natural Products Chemistry, College of Pharmacy, The University of Iowa, Iowa City, Journal of Medicinal Chemistry, Vol. 47, No. 26, 2004)
http://as.wiley.com/WileyCDA/WileyTitle/productCd-3527304312.html
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