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Title:
Arrow-Pushing in Organic Chemistry - An Easy Approach to Understanding Reaction Mechanisms |
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Division: Methods, Synthesis & Techniques / John Wiley & Son / English |
Author/Editor: Daniel E. Levy Star:  |
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ISBN: 0470171103 |
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Introduce Date: 2008年08月22日08:46 , Release Date: 2008年08月24日01:03 |
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Introducer: crisoo , Rate: 7/263 |
| Format: pdf(editorial) Download |
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| Description: |
Arrow-Pushing in Organic Chemistry: An Easy Approach to Understanding Reaction Mechanisms
Daniel E. Levy
ISBN: 978-0-470-17110-3
Paperback
302 pages
August 2008
Find an easier way to learn organic chemistry with Arrow-Pushing in Organic Chemistry: An Easy Approach to Understanding Reaction Mechanisms, a book that uses the arrow-pushing strategy to reduce this notoriously challenging topic to the study of interactions between organic acids and bases. Understand the fundamental reaction mechanisms relevant to organic chemistry, beginning with Sn2 reactions and progressing to Sn1 reactions and other reaction types. The problem sets in this book, an excellent supplemental text, emphasize the important aspects of each chapter and will reinforce the key ideas without requiring memorization.
About the Author.
Preface.
Chapter 1 Introduction.
1.1 Definition of Arrow Pushing.
1.2 Functional Groups.
1.3 Nucleophiles and Leaving Groups.
1.4 Summary.
1.5 Problems.
Chapter 2 Acids.
2.1 What are Acids?
2.2 What is Resonance?
2.3 How is Acidity Measured?
2.4 Relative Acidities.
2.5 Inductive Effects.
2.6 Inductive Effects and Relative Acidities.
2.7 Relative Acidities of Hydrocarbons.
2.8 Summary.
2.9 Problems.
Chapter 3 - Bases and Nucleophiles.
3.1 What are bases?
3.2 What are nucleophiles?
3.3 Leaving Groups.
3.4 Summary.
3.5 Problems.
Chapter 4 - SN2 Substitution Reactions.
4.1 What is an SN2 Reaction?
4.2 What are Leaving Groups?
4.3 Where can SN2 Reactions Occur?
4.4 SN2' Reactions.
4.5 Summary.
4.6 Problems.
N1 Substitution Reactions.
5.1 What is an SN1 Reaction?
5.2 How are SN1 Reactions Initiated?
5.3 The Carbocation.
5.3.1 Molecular Structure and Orbitals.
5.3.2 Stability of Carbocations.
5.4 Carbocation Rearrangements.
5.4.1 1,2-Hydride shifts.
5.4.2 1,2-Alkyl shifts.
5.4.3 Preventing Side Reactions.
5.5 Summary.
5.6 Problems.
Chapter 6.
6.1 E1 Eliminations.
6.2 E2 Eliminations.
6.3 How do Elimination Reactions Work?
6.4 Summary.
6.5 Problems.
Chapter 7 - Addition Reactions.
7.1 Addition of Halogens to Double Bonds.
7.2 Markovnikov's Rule.
7.3 Additions to Carbonyls.
7.3.1 1,2-Additions.
7.3.2 1,4-Additions.
7.3.3 Addition-Elimination Reactions.
7.4 Summary.
7.5 Problems.
Chapter 8-Moving Forward
8.1 Functional Group Manipulations.
8.2 Name Reactions.
8.3 Reagents.
8.4 Final Comments.
8.5 Problems.
Appendix 1-pKa Values of Protons Associated with Common Functional Groups.
Appendix 2-Answers and Explanations to Problems.
Chapter 1 Solutions.
Chapter 2 Solutions.
Chapter 3 Solutions.
Chapter 4 Solutions.
Chapter 5 Solutions.
Chapter 6 Solutions.
Chapter 7 Solutions.
Chapter 8 Solutions.
Appendix 3-Student Reaction Glossary.
Index.
DANIEL E. LEVY, PhD, is the Director of Synthetic Chemistry at Intradigm Corporation, pursuing delivery vehicles for siRNA therapeutics. He previously worked at Glycomed Inc., where he pursued the design and synthesis of novel glycomimetics for the treatment of cancer and inflammatory disorders; COR Therapeutics, where he pursued carbocyclic AMP analogs as inhibitors of type V adenylyl cyclase; and at Scios, Inc., where he pursued novel kinase inhibitors. Dr. Levy coauthored a book entitled The Chemistry of C-Glycosides and later collaborated with Dr. Péter Fügedi in the development and presentation of short courses entitled "Modern Synthetic Carbohydrate Chemistry" and "The Organic Chemistry of Sugars" offered by the American Chemical Society Continuing Education Department. Most recently, Dr. Levy coedited with Dr. Fügedi the book The Organic Chemistry of Sugars, based on the short course of the same name. Dr. Levy received his BS in chemistry from the University of California, Berkeley, and his PhD in organic chemistry from the Massachusetts Institute of Technology.
http://as.wiley.com/WileyCDA/Wil ... ableOfContents.html
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