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Title:
Molecular Modeling - Basic Principles and Applications |
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Division: General Biochemistry / John Wiley & Son / 英文版 |
Author/Editor: Hans-Dieter Höltje, Wolfgang Sippl, Didier Rognan, Gerd Folkers Star:  |
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ISBN: 3527315683 |
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Introduce Date: 2008年04月15日07:15 , Release Date: 2008年04月15日09:41 |
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Introducer: asymmsyn , Rate: 6/159 |
| Format: pdf(editorial) Download |
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| Appraiser: popeye.cn | Grade: +5 | Reason: ( 刚才下了01年第二版djvu格式，无意中又发现了第三版，一狠心，继续下载了吧。 ) | |
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| Description: |
Molecular Modeling: Basic Principles and Applications, 3rd Edition
Hans-Dieter Höltje, Wolfgang Sippl, Didier Rognan, Gerd Folkers
ISBN: 978-3-527-31568-0
Paperback
320 pages
March 2008
Wiley List Price: US $90.00
Description:
Ideal for beginners, this book explains the basics of modeling in a competent yet easily understandable way. Following complete sections on the modeling of small molecules, protein modeling and chemogenomics, completely worked-out examples show the way to the reader's first modeling experiment.
This new, third edition features a new chapter on chemogenomics, reflecting the trend towards 'chemical biology', as well as the protein modeling example being completely rewritten for a better 'feel' of modeling complex biomolecules.
The authors are experienced university teachers who regularly hold courses on molecular modeling, making this a tried-and-tested text for teachers. It is equally valuable for experts, since it is the only book to evaluate the strengths and limitations of the molecular modeling techniques and software currently available.
Table of Contents:
Preface to the third Edition.
1. Introduction.
2. Small Molecules.
3. A Case Study for Small Molecule Modeling: Dopamine D3 Receptor Antagonists.
4. Introduction to Comparative Protein Modeling.
5. Virtual Screening and Docking.
6. Scope and Limits of Molecular Docking.
7. Chemogenomic Approaches to Rational Drug Design.
8. A Case Study for Protein Modeling: the Nuclear Hormone Receptor CAR as an example for Comparative Modeling and the Analysis of Protein-Ligand Complexes.
Index.
Author Information:
Hans-Dieter Höltje is director of the Institute of Pharmaceutical Chemistry at the Heinrich-Heine-Universität Düsseldorf (Germany) where he also holds the chair of Medicinal Chemistry. His main interest is the molecular mechanism of drug action.
Wolfgang Sippl is Professor of Pharmaceutical Chemistry at the Martin-Luther-University of Halle-Wittenberg (Germany). He is interested in 3D QSAR, molecular docking and molecular dynamics, and their applications in drug design and pharmacokinetics.
Didier Rognan leads the Drug Bioinformatics Group at the Laboratory for Molecular Pharmacochemistry in Illkirch (France). He is mainly interested in all aspects (method development, applications) of protein-based drug design and virtual screening.
Gerd Folkers is Professor of Pharmaceutical Chemistry at the ETH Zürich (Switzerland). The focus of his research is the molecular interation between drugs and their binding sites.
http://as.wiley.com/WileyCDA/WileyTitle/productCd-3527315683.html
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