该文是在老板的建议下专门为Biophys. Rev.写的，因为他是该期刊的Editorial Board 的member，有供稿的义务，呵呵。和之前那个Nano Today的综述（http://forum.chem8.org/thread-59351-1-1.html）不同的是，该文主要侧重总结了荧光的金纳米簇在荧光生物成像方面的应用进展，而且考虑到该期刊的读者群主要是生物物理领域的研究者，所以写作表达上也有所不同。投稿过程相对比较慢，从投稿到接受花了差不多四个月时间，好在最后直接接受。
Gold nanoclusters as novel optical probes for in vitro and in vivo fluorescence imaging
Li Shang and G. Ulrich Nienhaus
Fluorescent probes play an important role in the development of fluorescence-based imaging techniques for life sciences research. Gold nanoclusters (AuNCs) are a novel type of fluorescent nanomaterials which have attracted great interest in recent years. Composed of only a few atoms, these ultrasmall AuNCs exhibit quantum confinement effects and molecule-like properties. Fluorescent AuNCs have an attractive set of features including ultrasmall size, good biocompatibility and photostability, and tunable emission in the red to near-infrared spectral region, which make them promising as fluorescent labels for biological imaging. Examples of their application include live cell labeling, cancer cell targeting, cellular apoptosis monitoring, and in vivo tumor imaging. Here, we present a brief overview of recent advances in utilizing these emissive ultrasmall AuNCs as optical probes for in vitro and in vivo fluorescence imaging.
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